Nature Communications (Dec 2020)

Modelling genetic mosaicism of neurodevelopmental disorders in vivo by a Cre-amplifying fluorescent reporter

  • Francesco Trovato,
  • Riccardo Parra,
  • Enrico Pracucci,
  • Silvia Landi,
  • Olga Cozzolino,
  • Gabriele Nardi,
  • Federica Cruciani,
  • Vinoshene Pillai,
  • Laura Mosti,
  • Andrzej W. Cwetsch,
  • Laura Cancedda,
  • Laura Gritti,
  • Carlo Sala,
  • Chiara Verpelli,
  • Andrea Maset,
  • Claudia Lodovichi,
  • Gian Michele Ratto

DOI
https://doi.org/10.1038/s41467-020-19864-w
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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Genetic mosaicism is frequently present in monogenic diseases of the central nervous system. Here the authors design a dual-colour reporter system that can be used to tune the degree of mosaicism in mouse models.