Nature Communications (Jul 2019)
Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling
- Brian D. Robinson,
- Panagiotis J. Vlachostergios,
- Bhavneet Bhinder,
- Weisi Liu,
- Kailyn Li,
- Tyler J. Moss,
- Rohan Bareja,
- Kyung Park,
- Peyman Tavassoli,
- Joanna Cyrta,
- Scott T. Tagawa,
- David M. Nanus,
- Himisha Beltran,
- Ana M. Molina,
- Francesca Khani,
- Juan Miguel Mosquera,
- Evanguelos Xylinas,
- Shahrokh F. Shariat,
- Douglas S. Scherr,
- Mark A. Rubin,
- Seth P. Lerner,
- Surena F. Matin,
- Olivier Elemento,
- Bishoy M. Faltas
Affiliations
- Brian D. Robinson
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Panagiotis J. Vlachostergios
- Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine
- Bhavneet Bhinder
- Department of Physiology and Biophysics, Weill Cornell Medicine
- Weisi Liu
- Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine
- Kailyn Li
- Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine
- Tyler J. Moss
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Rohan Bareja
- Department of Physiology and Biophysics, Weill Cornell Medicine
- Kyung Park
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Peyman Tavassoli
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Joanna Cyrta
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Scott T. Tagawa
- Department of Urology, Weill Cornell Medicine
- David M. Nanus
- Department of Urology, Weill Cornell Medicine
- Himisha Beltran
- Department of Urology, Weill Cornell Medicine
- Ana M. Molina
- Department of Urology, Weill Cornell Medicine
- Francesca Khani
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Juan Miguel Mosquera
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Evanguelos Xylinas
- Department of Urology, Weill Cornell Medicine
- Shahrokh F. Shariat
- Department of Urology, Weill Cornell Medicine
- Douglas S. Scherr
- Department of Urology, Weill Cornell Medicine
- Mark A. Rubin
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Seth P. Lerner
- Scott Department of Urology, Baylor College of Medicine
- Surena F. Matin
- Department of Urology, The University of Texas MD Anderson Cancer Center
- Olivier Elemento
- Englander Institute for Precision Medicine, Weill Cornell Medicine
- Bishoy M. Faltas
- Englander Institute for Precision Medicine, Weill Cornell Medicine
- DOI
- https://doi.org/10.1038/s41467-019-10873-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Upper tract urothelial carcinoma (UTUC) is an aggressive cancer and largely uncharacterised cancer. Here, Faltas and colleagues report its distinctive molecular and immune landscape compared to urothelial carcinoma of the bladder and explore the role of FGFR3 signaling in UTUC biology.
