Nature Communications (Jan 2017)
Long non-coding RNA Linc-RAM enhances myogenic differentiation by interacting with MyoD
- Xiaohua Yu,
- Yong Zhang,
- Tingting Li,
- Zhao Ma,
- Haixue Jia,
- Qian Chen,
- Yixia Zhao,
- Lili Zhai,
- Ran Zhong,
- Changyin Li,
- Xiaoting Zou,
- Jiao Meng,
- Antony K. Chen,
- Pier Lorenzo Puri,
- Meihong Chen,
- Dahai Zhu
Affiliations
- Xiaohua Yu
- Chinese Academy of Medical Sciences and Department of Biochemistry and Molecular Biology, The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College
- Yong Zhang
- Chinese Academy of Medical Sciences and Department of Biochemistry and Molecular Biology, The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College
- Tingting Li
- Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University Health Science Center
- Zhao Ma
- Department of Biomedical Engineering, College of Engineering, Peking University
- Haixue Jia
- Chinese Academy of Medical Sciences and Department of Biochemistry and Molecular Biology, The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College
- Qian Chen
- Chinese Academy of Medical Sciences and Department of Biochemistry and Molecular Biology, The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College
- Yixia Zhao
- Chinese Academy of Medical Sciences and Department of Biochemistry and Molecular Biology, The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College
- Lili Zhai
- Chinese Academy of Medical Sciences and Department of Biochemistry and Molecular Biology, The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College
- Ran Zhong
- Chinese Academy of Medical Sciences and Department of Biochemistry and Molecular Biology, The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College
- Changyin Li
- Chinese Academy of Medical Sciences and Department of Biochemistry and Molecular Biology, The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College
- Xiaoting Zou
- Chinese Academy of Medical Sciences and Department of Biochemistry and Molecular Biology, The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College
- Jiao Meng
- Chinese Academy of Medical Sciences and Department of Biochemistry and Molecular Biology, The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College
- Antony K. Chen
- Department of Biomedical Engineering, College of Engineering, Peking University
- Pier Lorenzo Puri
- Developmental Aging and Regeneration Program, Sanford-Burnham-Prebys Medical Discovery Institute
- Meihong Chen
- Chinese Academy of Medical Sciences and Department of Biochemistry and Molecular Biology, The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College
- Dahai Zhu
- Chinese Academy of Medical Sciences and Department of Biochemistry and Molecular Biology, The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College
- DOI
- https://doi.org/10.1038/ncomms14016
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
Long non-coding RNAs are important regulators of many diverse biological processes. Here the authors describe Linc-RAM, which regulates myogenesis by binding MyoD and promoting the assembly of the MyoD–Baf60c–Brg1 complex at target genes.
