Frontiers in Microbiology (Jun 2023)
16S rRNA gene sequencing reveals the correlation between the gut microbiota and the susceptibility to pathological scars
- Ming Li,
- Ming Li,
- Ming Li,
- Minghao Li,
- Minghao Li,
- Minghao Li,
- Yingting Dai,
- Yingting Dai,
- Yingting Dai,
- Dang Li,
- Han Yu,
- Jian Liu,
- Hangqi Gao,
- Hangqi Gao,
- Hangqi Gao,
- Yi Zhong,
- Yi Zhong,
- Yi Zhong,
- Mingquan Huang,
- Mingquan Huang,
- Mingquan Huang,
- Jing Lin,
- Jing Lin,
- Jing Lin,
- Yide Xie,
- Yide Xie,
- Yide Xie,
- Zhihui Guo,
- Zhihui Guo,
- Zhihui Guo,
- Xiaosong Chen,
- Xiaosong Chen,
- Xiaosong Chen
Affiliations
- Ming Li
- Department of Plastic Surgery and Regenerative Medicine, Fujian Medical University Union Hospital, Fuzhou, China
- Ming Li
- Department of Plastic Surgery and Regenerative Medicine Institute, Fujian Medical University, Fuzhou, China
- Ming Li
- Engineering Research Center of Tissue and Organ Regeneration, Fujian Province University, Fuzhou, China
- Minghao Li
- Department of Plastic Surgery and Regenerative Medicine, Fujian Medical University Union Hospital, Fuzhou, China
- Minghao Li
- Department of Plastic Surgery and Regenerative Medicine Institute, Fujian Medical University, Fuzhou, China
- Minghao Li
- Engineering Research Center of Tissue and Organ Regeneration, Fujian Province University, Fuzhou, China
- Yingting Dai
- Department of Plastic Surgery and Regenerative Medicine, Fujian Medical University Union Hospital, Fuzhou, China
- Yingting Dai
- Department of Plastic Surgery and Regenerative Medicine Institute, Fujian Medical University, Fuzhou, China
- Yingting Dai
- Engineering Research Center of Tissue and Organ Regeneration, Fujian Province University, Fuzhou, China
- Dang Li
- Nursing Department of Fujian Medical University Union Hospital, Fuzhou, China
- Han Yu
- Department of Dermatology, Pingtan Comprehensive Experimental Area Hospital, Fuzhou, China
- Jian Liu
- Fuzhou MineButy Clinics, Fuzhou, China
- Hangqi Gao
- Department of Plastic Surgery and Regenerative Medicine, Fujian Medical University Union Hospital, Fuzhou, China
- Hangqi Gao
- Department of Plastic Surgery and Regenerative Medicine Institute, Fujian Medical University, Fuzhou, China
- Hangqi Gao
- Engineering Research Center of Tissue and Organ Regeneration, Fujian Province University, Fuzhou, China
- Yi Zhong
- Department of Plastic Surgery and Regenerative Medicine, Fujian Medical University Union Hospital, Fuzhou, China
- Yi Zhong
- Department of Plastic Surgery and Regenerative Medicine Institute, Fujian Medical University, Fuzhou, China
- Yi Zhong
- Engineering Research Center of Tissue and Organ Regeneration, Fujian Province University, Fuzhou, China
- Mingquan Huang
- Department of Plastic Surgery and Regenerative Medicine, Fujian Medical University Union Hospital, Fuzhou, China
- Mingquan Huang
- Department of Plastic Surgery and Regenerative Medicine Institute, Fujian Medical University, Fuzhou, China
- Mingquan Huang
- Engineering Research Center of Tissue and Organ Regeneration, Fujian Province University, Fuzhou, China
- Jing Lin
- Department of Plastic Surgery and Regenerative Medicine, Fujian Medical University Union Hospital, Fuzhou, China
- Jing Lin
- Department of Plastic Surgery and Regenerative Medicine Institute, Fujian Medical University, Fuzhou, China
- Jing Lin
- Engineering Research Center of Tissue and Organ Regeneration, Fujian Province University, Fuzhou, China
- Yide Xie
- Department of Plastic Surgery and Regenerative Medicine, Fujian Medical University Union Hospital, Fuzhou, China
- Yide Xie
- Department of Plastic Surgery and Regenerative Medicine Institute, Fujian Medical University, Fuzhou, China
- Yide Xie
- Engineering Research Center of Tissue and Organ Regeneration, Fujian Province University, Fuzhou, China
- Zhihui Guo
- Department of Plastic Surgery and Regenerative Medicine, Fujian Medical University Union Hospital, Fuzhou, China
- Zhihui Guo
- Department of Plastic Surgery and Regenerative Medicine Institute, Fujian Medical University, Fuzhou, China
- Zhihui Guo
- Engineering Research Center of Tissue and Organ Regeneration, Fujian Province University, Fuzhou, China
- Xiaosong Chen
- Department of Plastic Surgery and Regenerative Medicine, Fujian Medical University Union Hospital, Fuzhou, China
- Xiaosong Chen
- Department of Plastic Surgery and Regenerative Medicine Institute, Fujian Medical University, Fuzhou, China
- Xiaosong Chen
- Engineering Research Center of Tissue and Organ Regeneration, Fujian Province University, Fuzhou, China
- DOI
- https://doi.org/10.3389/fmicb.2023.1215884
- Journal volume & issue
-
Vol. 14
Abstract
The gut microbiome profile in patients with pathological scars remains rarely known, especially those patients who are susceptible to pathological scars. Previous studies demonstrated that gut microbial dysbiosis can promote the development of a series of diseases via the interaction between gut microbiota and host. The current study aimed to explore the gut microbiota of patients who are prone to suffer from pathological scars. 35 patients with pathological scars (PS group) and 40 patients with normal scars (NS group) were recruited for collection of fecal samples to sequence the 16S ribosomal RNA (16S rRNA) V3-V4 region of gut microbiota. Alpha diversity of gut microbiota showed a significant difference between NS group and PS group, and beta diversity indicated that the composition of gut microbiota in NS and PS participants was different, which implied that dysbiosis exhibits in patients who are susceptible to pathological scars. Based on phylum, genus, species levels, we demonstrated that the changing in some gut microbiota (Firmicutes; Bacteroides; Escherichia coli, etc.) may contribute to the occurrence or development of pathological scars. Moreover, the interaction network of gut microbiota in NS and PS group clearly revealed the different interaction model of each group. Our study has preliminary confirmed that dysbiosis exhibits in patients who are susceptible to pathological scars, and provide a new insight regarding the role of the gut microbiome in PS development and progression.
Keywords
