INCREASED FAT INTAKE MAY STABILIZED CKD PROGRESSION IN LOW-FAT INTAKE PATIENTS

Abstract

Dietary intervention is important in patients with chronic kidney disease (CKD). Low protein diet maybe beneficial in slowing progression of CKD. However, little is known about the association between CKD progression and the other dietary compositions. We perform a prospective study by using 24 -hr dietary recall to determine the dietary conditions and modify the inadequate nutrient intake in CKD patients within one year. Total 35 adult patients in CKD stage 3–5 were enrolled. The average daily intake of calories, proteins, fats and carbohydrates were 20.5±7.4 Kcal/Kg/day, 0.7±0.2 g/Kg/day, 0.5±0.3 g/Kg/day and 3.1±1.2 g/Kg/day in the study entry. Fats component accounted for only 24.3±7.5 % of daily calories intake. After an observational period of 6 months, correction of fats intake by education was done in the later 6 months. The mean intake of calories and fats were increased to 24.9±7.6 Kcal/Kg/day and 0.9±0.3 g/Kg/day (p=0.035, 0.000 respectively) in the end. The slop of 1/SCr between first 6 months and later 6 months did not change significantly (−0.0016 vs. −0.0020, p=0.872). Serum cholesterol and triglyceride levels were within normal range. Inadequate calories intake will induce excessive protein catabolism, which can cause accumulation of uremic toxins and acceleration of renal failure. Increasing fats intake is an easy way to achieve adequate calories acquirement and may stabilize the progression of CKD especially in low-fat intake patients.