Emerging Infectious Diseases (Jun 2013)

BSE-associated Prion-Amyloid Cardiomyopathy in Primates

  • Susanne Krasemann,
  • Giulia Mearini,
  • Elisabeth Krämer,
  • Katja Wagenführ,
  • Walter Schulz-Schaeffer,
  • Melanie Neumann,
  • Walter Bodemer,
  • Franz-Josef Kaup,
  • Michael Beekes,
  • Lucie Carrier,
  • Adriano Aguzzi,
  • Markus Glatzel

DOI
https://doi.org/10.3201/eid1906.120906
Journal volume & issue
Vol. 19, no. 6
pp. 985 – 988

Abstract

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Prion amyloidosis occurred in the heart of 1 of 3 macaques intraperitoneally inoculated with bovine spongiform encephalopathy prions. This macaque had a remarkably long duration of disease and signs of cardiac distress. Variant Creutzfeldt-Jakob disease, caused by transmission of bovine spongiform encephalopathy to humans, may manifest with cardiac symptoms from prion-amyloid cardiomyopathy.

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