ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis

Jia-Shu Yang; Jia-Wei Hsu; Seung-Yeol Park; Stella Y. Lee; Jian Li; Ming Bai; Claudia Alves; William Tseng; Xavier Michelet; I-Cheng Ho; Victor W. Hsu

doi:10.1038/s41467-019-11932-0

Nature Communications (Sep 2019)

ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis

Jia-Shu Yang,
Jia-Wei Hsu,
Seung-Yeol Park,
Stella Y. Lee,
Jian Li,
Ming Bai,
Claudia Alves,
William Tseng,
Xavier Michelet,
I-Cheng Ho,
Victor W. Hsu

Affiliations

Jia-Shu Yang: Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, and Department of Medicine, Harvard Medical School
Jia-Wei Hsu: Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, and Department of Medicine, Harvard Medical School
Seung-Yeol Park: Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, and Department of Medicine, Harvard Medical School
Stella Y. Lee: Division of Biology, Kansas State University
Jian Li: Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, and Department of Medicine, Harvard Medical School
Ming Bai: Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, and Department of Medicine, Harvard Medical School
Claudia Alves: Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, and Department of Medicine, Harvard Medical School
William Tseng: Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, and Department of Medicine, Harvard Medical School
Xavier Michelet: Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, and Department of Medicine, Harvard Medical School
I-Cheng Ho: Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, and Department of Medicine, Harvard Medical School
Victor W. Hsu: Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, and Department of Medicine, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-019-11932-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

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Intracellular vesicle transport can be regulated by Brefeldin‐A ADP‐Ribosylated Substrate (BARS) during vesicle fission. Here, the authors show that NADH generated by aldehyde dehydrogenase 7A1 (ALDH7A1) inhibits intracellular transport by targeting BARS and inhibiting COPI vesicle fission during situations of energy deprivation

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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