Radiation induced skin reactions in primary cutaneous lymphoma patients: A review

Abstract

This review highlights the issue of radiation-induced skin reactions (RISR), emphasizes the high frequency of RISR in patients with cutaneous lymphomas undergoing radiation therapy, and analyzes numerous pathological processes that occur in the skin as a result of ionizing radiation exposure. The review systematically examines external and internal factors influencing the development of RISR, compares diagnostic methods, discusses preventive measures and treatments for radiation dermatitis, and describes the mechanisms of action for drugs used in RISR prophylaxis and treatment. RISR remains a significant problem in radiation therapy, characterized by a high frequency, a wide range of clinical manifestations, and an impact on patients quality of life. The mechanisms, diagnosis, prevention, and treatment of RISR are considered.

Keywords

• radiation-induced skin reaction
• radiotherapy
• total skin irradiation
• radiodermatitis
• t-cell lymphomas