PLoS ONE (Jan 2014)

Sugar-sweetened beverage intake and cancer recurrence and survival in CALGB 89803 (Alliance).

  • Michael A Fuchs,
  • Kaori Sato,
  • Donna Niedzwiecki,
  • Xing Ye,
  • Leonard B Saltz,
  • Robert J Mayer,
  • Rex B Mowat,
  • Renaud Whittom,
  • Alexander Hantel,
  • Al Benson,
  • Daniel Atienza,
  • Michael Messino,
  • Hedy Kindler,
  • Alan Venook,
  • Shuji Ogino,
  • Kana Wu,
  • Walter C Willett,
  • Edward L Giovannucci,
  • Jeffrey A Meyerhardt

DOI
https://doi.org/10.1371/journal.pone.0099816
Journal volume & issue
Vol. 9, no. 6
p. e99816

Abstract

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BACKGROUND:In colon cancer patients, obesity, sedentary lifestyle, and high dietary glycemic load have been associated with increased risk of cancer recurrence. High sugar-sweetened beverage intake has been associated with obesity, diabetes, and cardio-metabolic diseases, but the influence on colon cancer survival is unknown. METHODS:We assessed the association between sugar-sweetened beverage consumption on cancer recurrence and mortality in 1,011 stage III colon cancer patients who completed food frequency questionnaires as part of a U.S. National Cancer Institute-sponsored adjuvant chemotherapy trial. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with Cox proportional hazard models. RESULTS:Patients consuming ≥ 2 servings of sugar-sweetened beverages per day experienced an adjusted HR for disease recurrence or mortality of 1.67 (95% CI, 1.04-2.68), compared with those consuming <2 servings per month (P(trend) = 0.02). The association of sugar-sweetened beverages on cancer recurrence or mortality appeared greater among patients who were both overweight (body mass index ≥ 2 5 kg/m(2)) and less physically active (metabolic equivalent task-hours per week <18) (HR = 2.22; 95% CI, 1.29-3.81, P(trend) = 0.0025). CONCLUSION:Higher sugar-sweetened beverage intake was associated with a significantly increased risk of cancer recurrence and mortality in stage III colon cancer patients.