Nature Communications (Mar 2016)
Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg2+ homeostasis and cytoskeletal architecture
- Simon Stritt,
- Paquita Nurden,
- Remi Favier,
- Marie Favier,
- Silvia Ferioli,
- Sanjeev K. Gotru,
- Judith M M. van Eeuwijk,
- Harald Schulze,
- Alan T. Nurden,
- Michele P. Lambert,
- Ernest Turro,
- Stephanie Burger-Stritt,
- Masayuki Matsushita,
- Lorenz Mittermeier,
- Paola Ballerini,
- Susanna Zierler,
- Michael A. Laffan,
- Vladimir Chubanov,
- Thomas Gudermann,
- Bernhard Nieswandt,
- Attila Braun
Affiliations
- Simon Stritt
- Chair of Experimental Biomedicine, University Hospital, University of Würzburg, Josef-Schneider-Strasse 2, 97078 Würzburg, Germany
- Paquita Nurden
- Chair of Experimental Biomedicine, University Hospital, University of Würzburg, Josef-Schneider-Strasse 2, 97078 Würzburg, Germany
- Remi Favier
- Assistance Publique—Hôpitaux de Paris, Haematological Laboratory, Armand Trousseau Children Hospital, 26 Avenue du Docteur Arnold-Netter, 75012 Paris, France
- Marie Favier
- Inserm U1170, Gustave Roussy, University Paris Sud, 114 Rue Edouard Vaillant, 94805 Villejuif, France
- Silvia Ferioli
- Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig-Maximilians University Munich, Goethestraße 33, 80336 Munich, Germany
- Sanjeev K. Gotru
- Chair of Experimental Biomedicine, University Hospital, University of Würzburg, Josef-Schneider-Strasse 2, 97078 Würzburg, Germany
- Judith M M. van Eeuwijk
- Chair of Experimental Biomedicine, University Hospital, University of Würzburg, Josef-Schneider-Strasse 2, 97078 Würzburg, Germany
- Harald Schulze
- Chair of Experimental Biomedicine, University Hospital, University of Würzburg, Josef-Schneider-Strasse 2, 97078 Würzburg, Germany
- Alan T. Nurden
- Institut Hospitalo-Universitaire LIRYC, Plateforme Technologique d'Innovation Biomédicale, Hôpital Xavier Arnozan, Avenue du Haut Lévêque, 33604 Pessac, France
- Michele P. Lambert
- Division of Haematology, Children’s Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, Pennsylvania 19104, USA
- Ernest Turro
- Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Francis Crick Ave, Cambridge CB2 0S, UK
- Stephanie Burger-Stritt
- Department of Internal Medicine I, Endocrinology and Diabetes Unit, University Hospital of Würzburg, Oberdürrbacher Strasse 6, 97080 Würzburg, Germany
- Masayuki Matsushita
- Department of Molecular & Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Okinawa 903-0215, Japan
- Lorenz Mittermeier
- Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig-Maximilians University Munich, Goethestraße 33, 80336 Munich, Germany
- Paola Ballerini
- Assistance Publique—Hôpitaux de Paris, Haematological Laboratory, Armand Trousseau Children Hospital, 26 Avenue du Docteur Arnold-Netter, 75012 Paris, France
- Susanna Zierler
- Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig-Maximilians University Munich, Goethestraße 33, 80336 Munich, Germany
- Michael A. Laffan
- Centre for Haematology, Hammersmith Campus, Imperial College Academic Health Sciences Centre, Imperial College London, Du Cane Road, London SW7 2AZ, UK
- Vladimir Chubanov
- Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig-Maximilians University Munich, Goethestraße 33, 80336 Munich, Germany
- Thomas Gudermann
- Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig-Maximilians University Munich, Goethestraße 33, 80336 Munich, Germany
- Bernhard Nieswandt
- Chair of Experimental Biomedicine, University Hospital, University of Würzburg, Josef-Schneider-Strasse 2, 97078 Würzburg, Germany
- Attila Braun
- Chair of Experimental Biomedicine, University Hospital, University of Würzburg, Josef-Schneider-Strasse 2, 97078 Würzburg, Germany
- DOI
- https://doi.org/10.1038/ncomms11097
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
Although Mg2+is vital for platelet activation and aggregation, its regulation in these cells is still largely unknown. Here, the authors show that TRPM7, a cation channel and a protein kinase, regulates thrombopoiesis and platelet size by affecting the cytoskeleton of these cells in mice and humans.
