Nature Communications (Mar 2021)

Metabolic responses to mild cold acclimation in type 2 diabetes patients

  • Carlijn M. E. Remie,
  • Michiel P. B. Moonen,
  • Kay H. M. Roumans,
  • Emmani B. M. Nascimento,
  • Anne Gemmink,
  • Bas Havekes,
  • Gert Schaart,
  • Esther Kornips,
  • Peter J. Joris,
  • Vera B. Schrauwen-Hinderling,
  • Joris Hoeks,
  • Sander Kersten,
  • Matthijs K. C. Hesselink,
  • Esther Phielix,
  • Wouter D. van Marken Lichtenbelt,
  • Patrick Schrauwen

DOI
https://doi.org/10.1038/s41467-021-21813-0
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

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Cold acclimation has been shown to have beneficial metabolic effects, including improved insulin sensitivity in patients with type 2 diabetes. Here the authors show that a mild cold acclimation regiment during which overt shivering was prevented did not result in improved insulin sensitivity in a small group of patients with type 2 diabetes.