Research progress on the material basis and action mechanism of LuQi Formula in treating heart failure

Jiling Feng; Jiaying Guo; Huiyan Qu; Jirong Yan; Hongxi Xu; Hua Zhou

Pharmacological Research - Modern Chinese Medicine (Jun 2022)

Research progress on the material basis and action mechanism of LuQi Formula in treating heart failure

Jiling Feng,
Jiaying Guo,
Huiyan Qu,
Jirong Yan,
Hongxi Xu,
Hua Zhou

Affiliations

Jiling Feng: Institute of Cardiovascular Disease of Integrated Traditional Chinese and Western Medicine, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, No. 528, Zhangheng Road, Shanghai, China; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Shanghai 201203, China; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, No. 1200, Cailun Road, Shanghai 201203, China
Jiaying Guo: Institute of Cardiovascular Disease of Integrated Traditional Chinese and Western Medicine, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, No. 528, Zhangheng Road, Shanghai, China
Huiyan Qu: Institute of Cardiovascular Disease of Integrated Traditional Chinese and Western Medicine, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, No. 528, Zhangheng Road, Shanghai, China
Jirong Yan: Institute of Cardiovascular Disease of Integrated Traditional Chinese and Western Medicine, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, No. 528, Zhangheng Road, Shanghai, China
Hongxi Xu: Institute of Cardiovascular Disease of Integrated Traditional Chinese and Western Medicine, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, No. 528, Zhangheng Road, Shanghai, China; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Shanghai 201203, China; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, No. 1200, Cailun Road, Shanghai 201203, China; Corresponding authors at: Institute of Cardiovascular Disease of Integrated Traditional Chinese and Western Medicine, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, No. 528, Zhangheng Road, Shanghai, China (Hongxi Xu, Hua Zhou); School of Pharmacy, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Shanghai 201203, China (Hongxi Xu).
Hua Zhou: Institute of Cardiovascular Disease of Integrated Traditional Chinese and Western Medicine, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, No. 528, Zhangheng Road, Shanghai, China; Corresponding authors at: Institute of Cardiovascular Disease of Integrated Traditional Chinese and Western Medicine, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, No. 528, Zhangheng Road, Shanghai, China (Hongxi Xu, Hua Zhou); School of Pharmacy, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Shanghai 201203, China (Hongxi Xu).

Journal volume & issue: Vol. 3
p. 100080

Abstract

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Heart failure is the terminal stage of cardiovascular diseases. In the population-aging trend, it remains a serious social problem with high morbidity, mortality, and rehospitalization rates. Traditional Chinese medicine has long been used to treat heart failure. LuQi Formula was modified by Professor Zhou Hua of Shuguang Hospital, Shanghai, based on years of clinical experience and the concept of the “heart-kidney intersection.” It has been proven effective in the treatment of heart failure, and is beneficial in inhibiting myocardial fibrosis, decreasing collagen deposition and brain natriuretic peptide levels, improving heart function in rats with acute myocardial infarction, and affecting adenosine triphosphate production. In this review, we summarized the clinical and laboratory research on LuQi Formula, and the mechanism of the cardioprotective effect of each medicine in this recipe. This review offers a theoretical basis and research direction for further mechanistic studies on LuQi Formula to foster its development into new cardiovascular drugs.

Published in Pharmacological Research - Modern Chinese Medicine

ISSN: 2667-1425 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Other systems of medicine; Medicine: Therapeutics. Pharmacology
Website: https://www.sciencedirect.com/journal/pharmacological-research-modern-chinese-medicine

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