ADEMETIONINE THERAPY IN CHRONIC LIVER DISEASES

Abstract

Drug- and alcohol-induced liver injuries are the most common reason for the chronic liver diseases. For the past 10years, in Russia ademetionine products have been used in treatment of such diseases to provide detoxification and antioxidant effects, normalize the permeability of the cell membranes, accelerate regeneration of liver cells and slow down the development of fibrosis. The numerous studies showed that the use of ademetionine improves a protein synthesis in the liver, reduces the severity of lipid exchange violations, contributes to positive dynamics of serum biochemical parameters (ALP, GGTP, ALT, AST, bilirubin) and regresses clinical manifestations of the astenovegetative and dyspeptic syndromes, while tolerability of ademetionine is favorable [15, 17, 18].

Keywords

• drug-induced liver injury
• hepatotoxicity
• ademetionine