Nature Communications (Oct 2021)
Genetic investigation of fibromuscular dysplasia identifies risk loci and shared genetics with common cardiovascular diseases
- Adrien Georges,
- Min-Lee Yang,
- Takiy-Eddine Berrandou,
- Mark K. Bakker,
- Ozan Dikilitas,
- Soto Romuald Kiando,
- Lijiang Ma,
- Benjamin A. Satterfield,
- Sebanti Sengupta,
- Mengyao Yu,
- Jean-François Deleuze,
- Delia Dupré,
- Kristina L. Hunker,
- Sergiy Kyryachenko,
- Lu Liu,
- Ines Sayoud-Sadeg,
- Laurence Amar,
- Chad M. Brummett,
- Dawn M. Coleman,
- Valentina d’Escamard,
- Peter de Leeuw,
- Natalia Fendrikova-Mahlay,
- Daniella Kadian-Dodov,
- Jun Z. Li,
- Aurélien Lorthioir,
- Marco Pappaccogli,
- Aleksander Prejbisz,
- Witold Smigielski,
- James C. Stanley,
- Matthew Zawistowski,
- Xiang Zhou,
- Sebastian Zöllner,
- FEIRI investigators,
- International Stroke Genetics Consortium (ISGC) Intracranial Aneurysm Working Group,
- MEGASTROKE,
- Philippe Amouyel,
- Marc L. De Buyzere,
- Stéphanie Debette,
- Piotr Dobrowolski,
- Wojciech Drygas,
- Heather L. Gornik,
- Jeffrey W. Olin,
- Jerzy Piwonski,
- Ernst R. Rietzschel,
- Ynte M. Ruigrok,
- Miikka Vikkula,
- Ewa Warchol Celinska,
- Andrzej Januszewicz,
- Iftikhar J. Kullo,
- Michel Azizi,
- Xavier Jeunemaitre,
- Alexandre Persu,
- Jason C. Kovacic,
- Santhi K. Ganesh,
- Nabila Bouatia-Naji
Affiliations
- Adrien Georges
- PARCC, INSERM, Université de Paris
- Min-Lee Yang
- Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School
- Takiy-Eddine Berrandou
- PARCC, INSERM, Université de Paris
- Mark K. Bakker
- Department of Neurology and Neurosurgery, University Medical Center Utrecht Brain Center, Utrecht University
- Ozan Dikilitas
- Department of Cardiovascular Medicine, Mayo Clinic
- Soto Romuald Kiando
- PARCC, INSERM, Université de Paris
- Lijiang Ma
- Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Benjamin A. Satterfield
- Department of Cardiovascular Medicine, Mayo Clinic
- Sebanti Sengupta
- Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School
- Mengyao Yu
- PARCC, INSERM, Université de Paris
- Jean-François Deleuze
- Centre National de Recherche en Génomique Humaine, Institut de Génomique, CEA and Fondation Jean Dausset-CEPH
- Delia Dupré
- PARCC, INSERM, Université de Paris
- Kristina L. Hunker
- Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School
- Sergiy Kyryachenko
- PARCC, INSERM, Université de Paris
- Lu Liu
- PARCC, INSERM, Université de Paris
- Ines Sayoud-Sadeg
- PARCC, INSERM, Université de Paris
- Laurence Amar
- PARCC, INSERM, Université de Paris
- Chad M. Brummett
- Department of Anesthesiology, Michigan Medicine, University of Michigan
- Dawn M. Coleman
- Vascular Surgery Section, Department of Surgery, Michigan Medicine, University of Michigan
- Valentina d’Escamard
- Cardiovascular Institute, Icahn School of Medicine at Mount Sinai
- Peter de Leeuw
- Department of Internal Medicine, Division of General Internal Medicine, Section Vascular Medicine, Maastricht University Medical Centre, Maastricht University
- Natalia Fendrikova-Mahlay
- Heart and Vascular Institute, Cleveland Clinic
- Daniella Kadian-Dodov
- Zena and Michael A. Wiener Cardiovascular Institute and Marie-Josée and Henry R, Kravis Center for Cardiovascular Health Icahn School of Medicine at Mount Sinai
- Jun Z. Li
- Department of Human Genetics, University of Michigan Medical School
- Aurélien Lorthioir
- PARCC, INSERM, Université de Paris
- Marco Pappaccogli
- Division of Cardiology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain
- Aleksander Prejbisz
- Department of Hypertension, National Institute of Cardiology
- Witold Smigielski
- Department of Demography, University of Lodz
- James C. Stanley
- Vascular Surgery Section, Department of Surgery, Michigan Medicine, University of Michigan
- Matthew Zawistowski
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health
- Xiang Zhou
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health
- Sebastian Zöllner
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health
- FEIRI investigators
- International Stroke Genetics Consortium (ISGC) Intracranial Aneurysm Working Group
- MEGASTROKE
- Philippe Amouyel
- Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Labex DISTALZ - Risk factors and molecular determinants of aging-related disease
- Marc L. De Buyzere
- Department of Cardiovascular Diseases, Ghent University and Ghent University Hospital
- Stéphanie Debette
- Department of Neurology, Bordeaux University Hospital, Inserm U1219
- Piotr Dobrowolski
- Department of Hypertension, National Institute of Cardiology
- Wojciech Drygas
- Department of Epidemiology, Cardiovascular Disease Prevention, and Health Promotion, National Institute of Cardiology
- Heather L. Gornik
- Heart and Vascular Institute, Cleveland Clinic
- Jeffrey W. Olin
- Zena and Michael A. Wiener Cardiovascular Institute and Marie-Josée and Henry R, Kravis Center for Cardiovascular Health Icahn School of Medicine at Mount Sinai
- Jerzy Piwonski
- Department of Epidemiology, Cardiovascular Disease Prevention, and Health Promotion, National Institute of Cardiology
- Ernst R. Rietzschel
- Department of Cardiovascular Diseases, Ghent University and Ghent University Hospital
- Ynte M. Ruigrok
- Department of Cardiovascular Medicine, Mayo Clinic
- Miikka Vikkula
- Human Molecular Genetics, de Duve Institute, Université Catholique de Louvain
- Ewa Warchol Celinska
- Department of Hypertension, National Institute of Cardiology
- Andrzej Januszewicz
- Department of Hypertension, National Institute of Cardiology
- Iftikhar J. Kullo
- Department of Cardiovascular Medicine, Mayo Clinic
- Michel Azizi
- Hypertension Unit, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou
- Xavier Jeunemaitre
- PARCC, INSERM, Université de Paris
- Alexandre Persu
- Division of Cardiology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain
- Jason C. Kovacic
- Zena and Michael A. Wiener Cardiovascular Institute and Marie-Josée and Henry R, Kravis Center for Cardiovascular Health Icahn School of Medicine at Mount Sinai
- Santhi K. Ganesh
- Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School
- Nabila Bouatia-Naji
- PARCC, INSERM, Université de Paris
- DOI
- https://doi.org/10.1038/s41467-021-26174-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Fibromuscular dysplasia is a cardiovascular disease affecting mostly women with a mostly unknown genetic basis. Here the authors have performed a genome-wide association meta-analysis of Fibromuscular dysplasia to identify genetic loci, some of which are shared with common cardiovascular disease and traits.
