Clinical symptoms and immune injury reflected by low CD4/CD8 ratio should increase the suspicion of HIV coinfection with tuberculosis
Li Li,
Zulipikaer Abudureheman,
XueMei Zhong,
Hui Gong,
Fan Yang,
Abuduweili Awuti,
Ayiguli Alimu,
Subinuer Yilamujiang,
DaYong Zheng,
XiaoGuang Zou
Affiliations
Li Li
Department of Respiratory and Critical Care Medicine, First People's Hospital of Kashi, Kashi, China; State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Xinjiang Medical University, Urumqi, China; Corresponding author. Department of Respiratory and Critical Care Medicine, First People's Hospital of Kashi, Kashi, China
Zulipikaer Abudureheman
Department of Clinical Research Center of Infectious Diseases (Pulmonary Tuberculosis), First People's Hospital of Kashi, Kashi, China
XueMei Zhong
Department of Respiratory and Critical Care Medicine, First People's Hospital of Kashi, Kashi, China
Hui Gong
Department of Clinical Research Center of Infectious Diseases (Pulmonary Tuberculosis), First People's Hospital of Kashi, Kashi, China
Fan Yang
Department of Infectious Diseases, First People's Hospital of Kashi, Kashi, China
Abuduweili Awuti
Department of Infectious Diseases, First People's Hospital of Kashi, Kashi, China
Ayiguli Alimu
Department of Clinical Research Center of Infectious Diseases (Pulmonary Tuberculosis), First People's Hospital of Kashi, Kashi, China
Subinuer Yilamujiang
Department of Clinical Research Center of Infectious Diseases (Pulmonary Tuberculosis), First People's Hospital of Kashi, Kashi, China
DaYong Zheng
Department of Respiratory and Critical Care Medicine, First People's Hospital of Kashi, Kashi, China; Corresponding author.
XiaoGuang Zou
Department of Respiratory and Critical Care Medicine, First People's Hospital of Kashi, Kashi, China; Corresponding author.
Background: Patients who are coinfected with human immunodeficiency virus 1 (HIV) and Mycobacterium tuberculosis (TB) benefit from timely diagnosis and treatment. In the present study frequencies of CD3+, CD4+, and CD8+ T cells among peripheral blood mononuclear cells (PBMCs) of patients in the Kashi region of China infected with HIV, TB, and both HIV and TB (HIV-TB) were investigated to provide a basis for rapid identification of coinfected patients. Methods: A total of 62 patients with HIV, TB, or HIV-TB who were first hospitalized at our institution were included in the study, as were 30 controls. PBMCs were isolated, and the frequencies of CD3+, CD4+, and CD8+ T cells were determined via flow cytometry. Results: The frequency of CD4+ T cells and the CD4/CD8 ratio were significantly lower in the HIV-TB group than in the other three groups. In fever patients the frequency of CD4+ T cells and the CD4/CD8 ratio were significantly lower in the HIV-TB group than in the HIV group and the TB group. In patients who exhibited rapid weight loss there were no significant differences in the frequency of CD4+ T cells or the CD4/CD8 ratio between the groups. The results of treatment were compared in the HIV, TB, and HIV-TB groups after 7 days, and there were obvious improvements in the frequency of CD4+ T cells and the CD4/CD8 ratio. Conclusion: Clinical symptoms and the degree of immune injury can heighten suspicion for HIV-TB coinfection.
