Cholesterol esters form supercooled lipid droplets whose nucleation is facilitated by triacylglycerols

Calvin Dumesnil; Lauri Vanharanta; Xavier Prasanna; Mohyeddine Omrane; Maxime Carpentier; Apoorva Bhapkar; Giray Enkavi; Veijo T. Salo; Ilpo Vattulainen; Elina Ikonen; Abdou Rachid Thiam

doi:10.1038/s41467-023-36375-6

Nature Communications (Feb 2023)

Cholesterol esters form supercooled lipid droplets whose nucleation is facilitated by triacylglycerols

Calvin Dumesnil,
Lauri Vanharanta,
Xavier Prasanna,
Mohyeddine Omrane,
Maxime Carpentier,
Apoorva Bhapkar,
Giray Enkavi,
Veijo T. Salo,
Ilpo Vattulainen,
Elina Ikonen,
Abdou Rachid Thiam

Affiliations

Calvin Dumesnil: Laboratoire de Physique de l’École normale supérieure, ENS, Université PSL, CNRS, Sorbonne Université, Université Paris Cité
Lauri Vanharanta: Department of Anatomy and Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki
Xavier Prasanna: Department of Physics, University of Helsinki
Mohyeddine Omrane: Laboratoire de Physique de l’École normale supérieure, ENS, Université PSL, CNRS, Sorbonne Université, Université Paris Cité
Maxime Carpentier: Laboratoire de Physique de l’École normale supérieure, ENS, Université PSL, CNRS, Sorbonne Université, Université Paris Cité
Apoorva Bhapkar: Laboratoire de Physique de l’École normale supérieure, ENS, Université PSL, CNRS, Sorbonne Université, Université Paris Cité
Giray Enkavi: Department of Physics, University of Helsinki
Veijo T. Salo: Department of Anatomy and Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki
Ilpo Vattulainen: Department of Physics, University of Helsinki
Elina Ikonen: Department of Anatomy and Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki
Abdou Rachid Thiam: Laboratoire de Physique de l’École normale supérieure, ENS, Université PSL, CNRS, Sorbonne Université, Université Paris Cité

DOI: https://doi.org/10.1038/s41467-023-36375-6
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 13

Abstract

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Dumesnil et al. report that cholesterol esters (CE), which only melt above body temperature, form supercooled liquid crystalline lipid droplets (LD). Triacylglycerols (TG) solubilize CE to help CE LD nucleation. Through clustering TGs in the ER membrane, seipin controls CE LD nucleation sites.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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