Nature Communications (Dec 2022)
Breast cancer prevention by short-term inhibition of TGFβ signaling
- Maša Alečković,
- Simona Cristea,
- Carlos R. Gil Del Alcazar,
- Pengze Yan,
- Lina Ding,
- Ethan D. Krop,
- Nicholas W. Harper,
- Ernesto Rojas Jimenez,
- Donghao Lu,
- Anushree C. Gulvady,
- Pierre Foidart,
- Marco Seehawer,
- Benedetto Diciaccio,
- Katherine C. Murphy,
- Jason Pyrdol,
- Jayati Anand,
- Kodie Garza,
- Kai W. Wucherpfennig,
- Rulla M. Tamimi,
- Franziska Michor,
- Kornelia Polyak
Affiliations
- Maša Alečković
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Simona Cristea
- Department of Data Science, Dana-Farber Cancer Institute
- Carlos R. Gil Del Alcazar
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Pengze Yan
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Lina Ding
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Ethan D. Krop
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Nicholas W. Harper
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Ernesto Rojas Jimenez
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Donghao Lu
- Channing Division of Network Medicine, Brigham and Women’s Hospital
- Anushree C. Gulvady
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Pierre Foidart
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Marco Seehawer
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Benedetto Diciaccio
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Katherine C. Murphy
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Jason Pyrdol
- Channing Division of Network Medicine, Brigham and Women’s Hospital
- Jayati Anand
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Kodie Garza
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Kai W. Wucherpfennig
- Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute
- Rulla M. Tamimi
- Channing Division of Network Medicine, Brigham and Women’s Hospital
- Franziska Michor
- Department of Data Science, Dana-Farber Cancer Institute
- Kornelia Polyak
- Department of Medical Oncology, Dana-Farber Cancer Institute
- DOI
- https://doi.org/10.1038/s41467-022-35043-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
TGFβ signalling is reported to regulate hormone-responsive mammary epithelial progenitors that are associated with breast cancer risk. Here, the authors find that short-term TGFBR1 inhibition prevents tumour formation in rat breast cancer models and identify a TGFBR1 inhibition-responsive sub-population of mammary epithelial cells, which is associated with human breast cancer risk.
