Epilepsy and Behavior Case Reports (Jan 2018)

Continuous monitoring devices and seizure patterns by glucose, time and lateralized seizure onset

  • Katie M. Kinnear,
  • Nicole M. Warner,
  • Alan M. Haltiner,
  • Michael J. Doherty

Journal volume & issue
Vol. 10
pp. 65 – 70

Abstract

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Objectives: To investigate if glucose levels influence seizure patterns. Materials and methods: In a patient with RNS/NeuroPace implanted bi-temporally and type 1 diabetes mellitus, seizure event times and onset locations were matched to continuous tissue glucose. Results: Left focal seizure (LFS, n = 22) glucoses averaged 169 mg/dL, while right focal seizure (RFS, n = 23) glucoses averaged 131 mg/dL (p = 0.03). LFS occurred at mean time 17:02 while RFS occurred at 04:23. LFS spread to the contralateral side (n = 19) more than RFS (n = 2). Conclusion: Seizure onset laterality and spread vary with glucose and time of seizure. Keywords: Stimulation, Hypometabolism, Nonketotic, Glucose, Insulin, Circadian