Онкогематология (Aug 2016)
Lineage switch in relapse of acute leukemia with rearrangement of MLL gene (KMT2A). literature review and case reports
- E. A. Zerkalenkova,
- O. I. Illarionova,
- A. N. Kazakova,
- N. I. Ponomareva,
- L. V. Baydun,
- E. Yu. Osipova,
- M. E. Dubrovina,
- A. M. Popov,
- T. V. Konyukhova,
- S. A. Plyasunova,
- N. V. Myakova,
- A. A. Maschan,
- Yu. V. Olshanskaya
Affiliations
- E. A. Zerkalenkova
- Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, 117997 Moscow, Samory Mashela str., 1
- O. I. Illarionova
- Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, 117997 Moscow, Samory Mashela str., 1
- A. N. Kazakova
- Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, 117997 Moscow, Samory Mashela str., 1
- N. I. Ponomareva
- Russian Children Clinical Hospital, 119571 Moscow, Leninskiy pr., 117
- L. V. Baydun
- Russian Children Clinical Hospital, 119571 Moscow, Leninskiy pr., 117
- E. Yu. Osipova
- Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, 117997 Moscow, Samory Mashela str., 1
- M. E. Dubrovina
- Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, 117997 Moscow, Samory Mashela str., 1
- A. M. Popov
- Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, 117997 Moscow, Samory Mashela str., 1
- T. V. Konyukhova
- Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, 117997 Moscow, Samory Mashela str., 1
- S. A. Plyasunova
- Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, 117997 Moscow, Samory Mashela str., 1
- N. V. Myakova
- Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, 117997 Moscow, Samory Mashela str., 1
- A. A. Maschan
- Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, 117997 Moscow, Samory Mashela str., 1
- Yu. V. Olshanskaya
- Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, 117997 Moscow, Samory Mashela str., 1
- DOI
- https://doi.org/10.17650/1818-8346-2016-11-2-21-29
- Journal volume & issue
-
Vol. 11,
no. 2
pp. 21 – 29
Abstract
Lineage switch is a rare phenomenon in which a transition from lymphoid to myeloid was observed in relapse of acute leukemia, or vice versa. This paper presents the four clinical case reports of acute lymphoblastic leukemia with MLL gene rearrangement (KMT2A) with myeloid phenotype in relapse.
Keywords
- acute lymphoblastic leukemia
- acute myeloid leukemia
- lineage switch
- kmt2a gene rearrangement
- immunophenotyping
