Nature Communications (Mar 2022)
Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging
- Adelaida R. Palla,
- Keren I. Hilgendorf,
- Ann V. Yang,
- Jaclyn P. Kerr,
- Aaron C. Hinken,
- Janos Demeter,
- Peggy Kraft,
- Nancie A. Mooney,
- Nora Yucel,
- David M. Burns,
- Yu Xin Wang,
- Peter K. Jackson,
- Helen M. Blau
Affiliations
- Adelaida R. Palla
- Blau Laboratory, Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine
- Keren I. Hilgendorf
- Jackson Laboratory, Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine
- Ann V. Yang
- Blau Laboratory, Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine
- Jaclyn P. Kerr
- GlaxoSmithKline Research and Development, Muscle Metabolism Discovery Performance Unit
- Aaron C. Hinken
- GlaxoSmithKline Research and Development, Muscle Metabolism Discovery Performance Unit
- Janos Demeter
- Jackson Laboratory, Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine
- Peggy Kraft
- Blau Laboratory, Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine
- Nancie A. Mooney
- Jackson Laboratory, Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine
- Nora Yucel
- Blau Laboratory, Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine
- David M. Burns
- Blau Laboratory, Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine
- Yu Xin Wang
- Blau Laboratory, Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine
- Peter K. Jackson
- Jackson Laboratory, Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine
- Helen M. Blau
- Blau Laboratory, Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-29150-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
Repair of muscle damage requires muscle stem cells, which lose regenerative capacity with aging. Here, the authors show that a sensory organelle, the primary cilium, is critical for muscle stem cell proliferation during regeneration and lost with aging.
