Comparative Evaluation of Isolated and Complex Use of Hexetidine and Photoditazine in Combination with Ultrasound Therapy in the Treatment of Purulent Wounds under Experimental Conditions

Abstract

Background: Currently, despite the significant success of the pharmaceutical industry in producing drugs with antibacterial activity, the treatment of soft tissue diseases accompanied by purulent-inflammatory processes within them remains one of the topical problems of general surgery. Not only the widespread introduction of antibacterial agents in practical medicine, but also the steady increase in the resistance of microorganisms to existing drugs leads to the need to search for new combinations aimed at the local treatment of purulent wounds. The purpose of our work was to study the course of the wound process in a purulent wound by using hexetidine and photoditazine in combination with ultrasound treatment. Methods and Results: This experimental study was carried out on 144 male Wistar rats. The course of the wound process was evaluated on a model of a purulent wound. The animals were divided into 4 equal groups (36 animals in each group), depending on their treatment. Treatment was carried out using daily dressings for 15 days. The dynamics of changes in the area of the wound were assessed by the planimetry method. The percentage of area reduction of the wound was calculated. A histological examination of a skin area (1.0 cm×1.5 cm) taken in the zone of a simulated purulent wound was carried out on Days 5 and 10 of the experiment. our study confirmed the effectiveness of the use of hexetidine, photoditazine, and a combination of them, along with ultrasound treatment, in the local treatment of a purulent wound. At the same time, the combined effect of an antiseptic and a photosensitizer showed significantly better results in the first and second phases of the course of the wound process than did their isolated use.

Keywords

• purulent wound
• hexetidine
• photoditazine
• ultrasound therapy
• methylcellulose