Frontiers in Chemistry (Mar 2021)

Diethyl Malonate-Based Turn-On Chemical Probe for Detecting Hydrazine and Its Bio-Imaging and Environmental Applications With Large Stokes Shift

  • Jianbo Qu,
  • Zhi-Hao Zhang,
  • Haitao Zhang,
  • Zhen-Tao Weng,
  • Jian-Yong Wang

DOI
https://doi.org/10.3389/fchem.2020.602125
Journal volume & issue
Vol. 8

Abstract

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Diethyl malonate-based fluorescent probe NE-N2H4 was constructed for monitoring hydrazine (N2H4). The novel probe NE-N2H4 exhibits good properties, such as large Stokes shift (about 125 nm), good selectivity, and low cytotoxicity. This sensing probe NE-N2H4 can be operated to detect hydrazine in living HeLa cells. Especially after soaking in probe solution, the thin-layer chromatography (TLC) plate could detect the vapor of hydrazine. Therefore, the probe NE-N2H4 might be used to monitor hydrazine in biosamples and environmental problem.

Keywords