Botanicals and Oral Stem Cell Mediated Regeneration: A Paradigm Shift from Artificial to Biological Replacement
Anami Ahuja,
Pankaj Kumar Tyagi,
Manoj Kumar,
Naveen Sharma,
Suraj Prakash,
Radha,
Deepak Chandran,
Sangram Dhumal,
Nadeem Rais,
Surinder Singh,
Abhijit Dey,
Marisennayya Senapathy,
Lejaniya Abdul Kalam Saleena,
Arjun Shanavas,
Pran Mohankumar,
Sureshkumar Rajalingam,
Yasodha Murugesan,
Marthandan Vishvanathan,
Sangeetha Kizhakkumkara Sathyaseelan,
Sabareeshwari Viswanathan,
Keerthana Krishna Kumar,
Suman Natta,
Mohamed Mekhemar
Affiliations
Anami Ahuja
Department of Biotechnology, Dr. A.P.J. Abdul Kalam Technical University, Lucknow 226031, India
Pankaj Kumar Tyagi
Department of Biotechnology, Noida Institute of Engineering & Technology, Greater Noida 201306, India
Manoj Kumar
Chemical and Biochemical Processing Division, ICAR–Central Institute for Research on Cotton Technology, Mumbai 400019, India
Naveen Sharma
Division of Biomedical Informatics, Indian Council of Medical Research, New Delhi 110029, India
Suraj Prakash
School of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management Sciences, Solan 173229, India
Radha
School of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management Sciences, Solan 173229, India
Deepak Chandran
Department of Veterinary Sciences and Animal Husbandry, Amrita School of Agricultural Sci-ences, Amrita Vishwa Vidyapeetham University, Coimbatore 642109, India
Sangram Dhumal
Division of Horticulture, RCSM College of Agriculture, Kolhapur 416004, India
Nadeem Rais
Department of Pharmacy, Bhagwant University, Ajmer 305004, India
Surinder Singh
Dr. S. S. Bhatnagar University Institute of Chemical Engineering and Technology, Panjab University, Chandigarh 160014, India
Abhijit Dey
Department of Life Sciences, Presidency University, 86/1 College Street, Kolkata 700073, India
Marisennayya Senapathy
Department of Rural Development and Agricultural Extension, College of Agriculture, Wolaita Sodo University, Wolaita Sodo P.O. Box 138, Ethiopia
Lejaniya Abdul Kalam Saleena
Department of Food Science and Nutrition, Faculty of Applied Sciences, UCSI University, Kuala Lampur 56000, Malaysia
Arjun Shanavas
Division of Medicine, Indian Veterinary Research Institute, Bareilly 243122, India
Pran Mohankumar
School of Agriculture and Biosciences, Karunya Institute of Technology and Sciences, Coimbatore 641114, India
Sureshkumar Rajalingam
Department of Agronomy, Amrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Coimbatore 642109, India
Yasodha Murugesan
Department of Agronomy, Amrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Coimbatore 642109, India
Marthandan Vishvanathan
Department of Seed Science and Technology, Amrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Coimbatore 642109, India
Sangeetha Kizhakkumkara Sathyaseelan
Department of Plantation Crops and Spices, Kerala Agricultural University, Vellanikkara, Thrissur 680656, India
Sabareeshwari Viswanathan
Department of Soil Science and Agricultural Chemistry, Amrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Coimbatore 642109, India
Keerthana Krishna Kumar
Department of Soil Science and Agricultural Chemistry, Amrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Coimbatore 642109, India
Suman Natta
ICAR—National Research Centre for Orchids, Pakyong 737106, India
Mohamed Mekhemar
Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Chris-tian-Albrecht’s University, 24105 Kiel, Germany
Stem cells are a well-known autologous pluripotent cell source, having excellent potential to develop into specialized cells, such as brain, skin, and bone marrow cells. The oral cavity is reported to be a rich source of multiple types of oral stem cells, including the dental pulp, mucosal soft tissues, periodontal ligament, and apical papilla. Oral stem cells were useful for both the regeneration of soft tissue components in the dental pulp and mineralized structure regeneration, such as bone or dentin, and can be a viable substitute for traditionally used bone marrow stem cells. In recent years, several studies have reported that plant extracts or compounds promoted the proliferation, differentiation, and survival of different oral stem cells. This review is carried out by following the PRISMA guidelines and focusing mainly on the effects of bioactive compounds on oral stem cell-mediated dental, bone, and neural regeneration. It is observed that in recent years studies were mainly focused on the utilization of oral stem cell-mediated regeneration of bone or dental mesenchymal cells, however, the utility of bioactive compounds on oral stem cell-mediated regeneration requires additional assessment beyond in vitro and in vivo studies, and requires more randomized clinical trials and case studies.
