MR imaging tracking of inflammation-activatable engineered neutrophils for targeted therapy of surgically treated glioma

Meiying Wu; Haixian Zhang; Changjun Tie; Chunhong Yan; Zhiting Deng; Qian Wan; Xin Liu; Fei Yan; Hairong Zheng

doi:10.1038/s41467-018-07250-6

Nature Communications (Nov 2018)

MR imaging tracking of inflammation-activatable engineered neutrophils for targeted therapy of surgically treated glioma

Meiying Wu,
Haixian Zhang,
Changjun Tie,
Chunhong Yan,
Zhiting Deng,
Qian Wan,
Xin Liu,
Fei Yan,
Hairong Zheng

Affiliations

Meiying Wu: Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
Haixian Zhang: Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
Changjun Tie: Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
Chunhong Yan: Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
Zhiting Deng: Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
Qian Wan: Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
Xin Liu: Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
Fei Yan: Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
Hairong Zheng: Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-018-07250-6
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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Imaging tracking of the migration of cell-based drug delivery systems are needed for expanding their clinical application for glioma. Here they report inflammation activatable engineered neutrophils containing doxorubicin-loaded magnetic mesoporous silica nanoparticles to image and actively target brain tumors after resection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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