Is Ovarian Mass Malignancy Prediction Accuracy Increased by Adding Serum CA125 Measurement to Sonographic Findings?

Abstract

Introduction & Objective: The aim of the present study is to determine the accuracy of malignancy prediction in adnexal mass if CA125 measurement is added to sonographic findings.Materials & Methods: In a cross sectional study, AUC of ROC Curve of malignancy prediction based on sonographic findings in comparison to a new model (OMPS2) based on sonography plus serum CA125 was calculated. Pathologic reports of 430 operated adnexal masses were included in the study. Logistic regression analysis was used. Results: New model (OMPS2) was constructed as follow: OMPS1+1.444 (if CA125=36-200) or 3.842 (if CA125 is above 200).AUC of ROC curve of malignancy prediction increased from 78.1% (based on OMPS1) to 84.3% (in OMPS2). Conclusion: Serum CA125 measurement in addition to sonography increased the accuracy of malignancy prediction in comparison to only sonography.

Keywords

• ca-125 antigen
• ovarian neoplasms
• ultrasonography