Structure and function of the Orc1 BAH-nucleosome complex

Pablo De Ioannes; Victor A. Leon; Zheng Kuang; Miao Wang; Jef D. Boeke; Andreas Hochwagen; Karim-Jean Armache

doi:10.1038/s41467-019-10609-y

Nature Communications (Jul 2019)

Structure and function of the Orc1 BAH-nucleosome complex

Pablo De Ioannes,
Victor A. Leon,
Zheng Kuang,
Miao Wang,
Jef D. Boeke,
Andreas Hochwagen,
Karim-Jean Armache

Affiliations

Pablo De Ioannes: Skirball Institute of Biomolecular Medicine, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine
Victor A. Leon: Department of Biology, New York University
Zheng Kuang: Institute for Systems Genetics, Department of Biochemistry and Molecular Pharmacology, NYU Langone Health
Miao Wang: Skirball Institute of Biomolecular Medicine, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine
Jef D. Boeke: Institute for Systems Genetics, Department of Biochemistry and Molecular Pharmacology, NYU Langone Health
Andreas Hochwagen: Department of Biology, New York University
Karim-Jean Armache: Skirball Institute of Biomolecular Medicine, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine

DOI: https://doi.org/10.1038/s41467-019-10609-y
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

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The Origin Recognition Complex (ORC) plays conserved and diverse roles in eukaryotes. Here the authors present the structure of a chromatin interacting domain of yeast Orc1 in complex with the nucleosome core particle, revealing that Orc1 interacts with the histone H4 tail irrespective of K16 acetylation; a modification that regulates accessibility to chromatin.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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