Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family

Nadia Sukusu Nielsen; Alessandra Zarantonello; Seandean Lykke Harwood; Kathrine Tejlgård Jensen; Katarzyna Kjøge; Ida B. Thøgersen; Leif Schauser; Jesper Lykkegaard Karlsen; Gregers R. Andersen; Jan J. Enghild

doi:10.1038/s41467-022-30758-x

Nature Communications (May 2022)

Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family

Nadia Sukusu Nielsen,
Alessandra Zarantonello,
Seandean Lykke Harwood,
Kathrine Tejlgård Jensen,
Katarzyna Kjøge,
Ida B. Thøgersen,
Leif Schauser,
Jesper Lykkegaard Karlsen,
Gregers R. Andersen,
Jan J. Enghild

Affiliations

Nadia Sukusu Nielsen: Department of Molecular Biology and Genetics, Aarhus University
Alessandra Zarantonello: Department of Molecular Biology and Genetics, Aarhus University
Seandean Lykke Harwood: Department of Molecular Biology and Genetics, Aarhus University
Kathrine Tejlgård Jensen: Department of Molecular Biology and Genetics, Aarhus University
Katarzyna Kjøge: Department of Molecular Biology and Genetics, Aarhus University
Ida B. Thøgersen: Department of Molecular Biology and Genetics, Aarhus University
Leif Schauser: QIAGEN Aarhus A/S
Jesper Lykkegaard Karlsen: Department of Molecular Biology and Genetics, Aarhus University
Gregers R. Andersen: Department of Molecular Biology and Genetics, Aarhus University
Jan J. Enghild: Department of Molecular Biology and Genetics, Aarhus University

DOI: https://doi.org/10.1038/s41467-022-30758-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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A2ML1 is a human protease inhibitor belonging to the A2M protein family. In this study, the authors determine structures of A2ML1 before and after protease inhibition and investigate its mechanism of action.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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