Антибиотики и Химиотерапия (May 2020)

The Quantitative Indices of ERCC1 Expression in Serous Ovarian Cancer Tissue and the Efficacy of First-Line Platinum-Based Chemotherapy

  • T. A. Bogush,
  • M. B. Stenina,
  • E. A. Bogush,
  • V. T. Zarkua,
  • S. A. Kalyuzhny,
  • I. A. Mamichev,
  • A. S. Tyulyandina,
  • S. A. Tyulyandin

Journal volume & issue
Vol. 63, no. 1-2
pp. 24 – 31

Abstract

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Platinum-based drugs are widely used in clinical practice. Their efficacy varies widely among patients, which may be due to a disruption of the expression of ERCC1 - excision repair protein. In the prospective study a strictly quantitative analysis of the ERCC1 protein expression was carried out in surgical biopsy specimens of serous ovarian cancer by flow cytometry. ERCC1 expression was revealed in 100% of cases, but the expression level of the marker (the percentage of cells expressing ERCC1) varied significantly between tumors: the minimum was 40%, the maximum - 77%, the median - 64.5%; the average - 64.3+9.0%. The analysis of the Kaplan-Mayer curves showed an inverse relationship between the expression of ERCC1 and the duration of the relapse-free period during a 40-month follow-up after the first-line platinum-taxane chemotherapy (p

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