<i>Cassia alata</i> (Linnaeus) Roxburgh for Skin: Natural Remedies for Atopic Dermatitis in Asia and Their Pharmacological Activities
Jessica-Ai-Lyn Yon,
Sue-Kei Lee,
Jing-Wen Keng,
Sek-Chuen Chow,
Kai-Bin Liew,
Swee-Sen Teo,
Wan Mastura Shaik Mossadeq,
Philip J. Marriott,
Gabriel Akyirem Akowuah,
Long Chiau Ming,
Bey Hing Goh,
Yik-Ling Chew
Affiliations
Jessica-Ai-Lyn Yon
Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur 56000, Malaysia
Sue-Kei Lee
Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur 56000, Malaysia
Jing-Wen Keng
Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur 56000, Malaysia
Sek-Chuen Chow
School of Science, Monash University Malaysia, Bandar Sunway 47500, Selangor Darul Ehsan, Malaysia
Kai-Bin Liew
Faculty of Pharmacy, University of Cyberjaya, Cyberjaya 63000, Malaysia
Swee-Sen Teo
Faculty of Applied Sciences, UCSI University, Kuala Lumpur 56000, Malaysia
Wan Mastura Shaik Mossadeq
Department of Veterinary Preclinical Sciences, Faculty of Veterinary Medicine, Universiti Putra Malaysia, UMP Serdang, Selangor 43400, Selangor Darul Ehsan, Malaysia
Philip J. Marriott
Australian Centre for Research on Separation Science, School of Chemistry, Monash University, Wellington Road, Clayton, VIC 3800, Australia
Gabriel Akyirem Akowuah
Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur 56000, Malaysia
Long Chiau Ming
School of Medical and Life Sciences, Sunway University, Sunway City 47500, Malaysia
Bey Hing Goh
Biofunctional Molecule Exploratory Research Group, School of Pharmacy, Monash University Malaysia, Bandar Sunway 47500, Selangor Darul Ehsan, Malaysia
Yik-Ling Chew
Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur 56000, Malaysia
Atopic dermatitis (AD) is an inflamed skin condition with relapsing pruritus and cutaneous physiological dysfunction. This skin disorder is widespread around the world and frequently affects infants, children and adults. Natural products with bioactive lead compounds are the source of natural medicines for complementary and alternative therapy in managing AD. Cassia alata has been used traditionally as a remedy for a variety of health issues. In Asian countries, it is used as an ethnomedicine to treat skin conditions such pityriasis versicolor, ringworm, scabies, shingles, urticaria and itching. According to previously published studies, the phytochemicals in C. alata may have a wide range of significant pharmacological effects. AD management is highlighted here, as this review explores the literature on the pharmacological effects of C. alata and its phytochemical content. Specifically, antibacterial, wound healing, anti-inflammatory and antioxidant effects are reviewed and discussed in relation to AD management.
