Correlation study on cystatin C and ischemic stroke

Abstract

Objective To investigate the relationship between serum cystatin C (Cys C) and patients with acute ischemic stroke. Methods The clinical and laboratory data of 115 patients with acute ischemic stroke and 110 controls were recorded and analyzed. Results The serum Cys C levels of patients in ischemic stroke group [(1.15 ± 0.34) mg/L] were higher than that of the control group [(0.99 ± 0.25) mg/L]. The difference between two groups was significant after correction of age and cardiovascular risk factors (t = -3.889, P = 0.000). It was found that age, Cys C, homocysteine (Hcy), type 2 diabetes mellitus [hemoglobin A1c (HbA1c), fructosamine (FRU)], smoking, alcohol consumption, hypertension and intima-media thickness (IMT) were risk factors for ischemic stroke on univariate Logistic regression analysis. The difference of serum Cys C level between the patients and controls was significant (P = 0.000), but through covariance analysis, after adjusted other risk factors, it was not significant (P = 0.875). Conclusion The serum Cys C levels of patients in ischemic stroke group is higher than the control group. It can be used as an indicator in the acute phase of ischemic stroke. The elevation of serum Cys C is a risk factor for ischemic stroke, but not an independent risk factor.

Keywords

• Brain ischemia
• Stroke
• Cysteine proteinase inhibitors
• Nephelometry and turbidimetry
• Risk factors
• Regression analysis