Infectious Agents and Cancer (Nov 2011)

Low frequency of human papillomavirus infection in conjunctival squamous cell carcinoma of Mexican patients

  • Peralta Raúl,
  • Valdivia Alejandra,
  • Estañol Perla,
  • Villegas Vanessa,
  • Pimienta Carolina,
  • Treviño Eugenio,
  • Marrero Daniel,
  • Mendoza Monica,
  • Jimenez Florinda,
  • Villalvazo Leonardo,
  • Tejeda Miriam,
  • Salcedo Mauricio

DOI
https://doi.org/10.1186/1750-9378-6-24
Journal volume & issue
Vol. 6, no. 1
p. 24

Abstract

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Abstract Background The relationship between Human Papillomavirus (HPV) infection and conjunctiva cancer is controversial. HPV detection will provide more information about the role of this infectious agent in the biology of conjunctiva cancer. In the present study, DNA extracted and purified from 36 Conjunctival Squamous Cell Carcinomas (CSCC) was evaluated by PCR for HPV DNA sequences. The results were correlated with the clinical and histopathological variables. Results The results showed that HPV DNA was present in 8 CSCC samples (22%); HPV16 was the sole type detected. Significant association was found between HPV detection and the limbus tumor subtype (p = 0.03). All the samples were non-metastatic squamous cell carcinoma. Conclusions The HPV presence in CSCC from Mexican patients is not a common event.

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