An association analysis to identify genetic variants linked to asthma and rhino-conjunctivitis in a cohort of Sicilian children

Gianluca Sottile; Giuliana Ferrante; Marta Torregrossa; Fabio Cibella; Giovanna Cilluffo; Salvatore Fasola; Riccardo Alessandro; Gregorio Seidita; Giovanni Viegi; Stefania La Grutta

doi:10.1186/s13052-019-0603-4

Italian Journal of Pediatrics (Jan 2019)

An association analysis to identify genetic variants linked to asthma and rhino-conjunctivitis in a cohort of Sicilian children

Gianluca Sottile,
Giuliana Ferrante,
Marta Torregrossa,
Fabio Cibella,
Giovanna Cilluffo,
Salvatore Fasola,
Riccardo Alessandro,
Gregorio Seidita,
Giovanni Viegi,
Stefania La Grutta

Affiliations

Gianluca Sottile: Department of Economics, Business and Statistical Science, University of Palermo
Giuliana Ferrante: Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza “G. D’Alessandro”, University of Palermo
Marta Torregrossa: National Research Council of Italy, Institute of Biomedicine and Molecular Immunology
Fabio Cibella: National Research Council of Italy, Institute of Biomedicine and Molecular Immunology
Giovanna Cilluffo: National Research Council of Italy, Institute of Biomedicine and Molecular Immunology
Salvatore Fasola: National Research Council of Italy, Institute of Biomedicine and Molecular Immunology
Riccardo Alessandro: National Research Council of Italy, Institute of Biomedicine and Molecular Immunology
Gregorio Seidita: Dipartimento di Biomedicina, Neuroscienze e Diagnostica avanzata, University of Palermo
Giovanni Viegi: National Research Council of Italy, Institute of Biomedicine and Molecular Immunology
Stefania La Grutta: Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza “G. D’Alessandro”, University of Palermo

DOI: https://doi.org/10.1186/s13052-019-0603-4
Journal volume & issue: Vol. 45, no. 1
pp. 1 – 6

Abstract

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Abstract Asthma and rhino-conjunctivitis are common chronic diseases in childhood. In this cross-sectional study, we performed a gene association analysis with current asthma and rhino-conjunctivitis in a cohort of Sicilian children aged 10–15 years. Overall, our findings reveal the importance of different genetic variants at 4p14, 16p12.1, 17q12, 6p12.2 and 17q21.1, identifying possible candidate genes responsible for susceptibility to asthma and rhino-conjunctivitis.

Published in Italian Journal of Pediatrics

ISSN: 1720-8424 (Print); 1824-7288 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Pediatrics
Website: https://ijponline.biomedcentral.com/

About the journal

Abstract

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