Wide-Field Choroidal Thickness Analysis after Half-Fluence Photodynamic Therapy Combined with Intravitreal Aflibercept Injection in Pachychoroid Neovasculopathy

Abstract

Background: Pachychoroid neovasculopathy (PNV) is a pachychoroid-spectrum disease. As blood circulation throughout the choroid may be involved in PNV pathogenesis, analysis using ultra-wide-field (UWF) fundus imaging is crucial. We evaluated choroidal thickness after half-fluence photodynamic therapy (PDT) combined with intravitreal aflibercept injection for PNV using UWF swept-source optical coherence tomography. Methods: Seventeen eyes with PNV that underwent half-fluence PDT with an adjuvant single intravitreal aflibercept injection were analyzed. To compare choroidal thicknesses in the central and peripheral choroids, we set subfields Results: Choroidal thickness in each subfield decreased significantly after half-fluence PDT (p Conclusions: Half-fluence PDT caused thinning of the entire choroid, especially in the central area, in PNV.

Keywords

• age-related macular degeneration
• pachychoroid neovasculopathy
• photodynamic therapy
• anti-vascular endothelial growth factor therapy
• ultra-wide-field optical coherent tomography