Current Issues in Molecular Biology (Nov 2023)

Modelling 3D Tumour Microenvironment In Vivo: A Tool to Predict Cancer Fate

  • Johanna Marines,
  • Francesca Lorenzini,
  • Karima Kissa,
  • Laura Fontenille

DOI
https://doi.org/10.3390/cimb45110569
Journal volume & issue
Vol. 45, no. 11
pp. 9076 – 9083

Abstract

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Recently, many studies demonstrated the fundamental role of the tumour microenvironment (TME) in cancer progression. Here, we describe a method to visualize in 3D the behaviour of tumours in zebrafish embryos. We highlight two major actors of the TME, macrophages and vessels. This valuable tool is transposable to Patient-Derived Xenograft imaging in order to predict the fate of malignant tumours according to the dynamics of their TME.

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