Impact of COVID-19 Vaccination on Mortality and Clinical Outcomes in Hemodialysis Patients
Rihong Hu,
Jiazhen Yin,
Tingfei He,
Yuxuan Zhu,
Ye Li,
Jinchi Gao,
Xiaomin Ye,
Lidan Hu,
Yayu Li
Affiliations
Rihong Hu
Key Laboratory of Kidney Disease Prevention and Control Technology, Department of Nephrology, Hangzhou Hospital of Traditional Chinese Medicine, 453 Tiyu Road, Xihu District, Hangzhou 310012, China
Jiazhen Yin
Hangzhou Clinical College, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, China
Tingfei He
Hangzhou Clinical College, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, China
Yuxuan Zhu
Hangzhou Clinical College, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, China
Ye Li
Hangzhou Clinical College, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, China
Jinchi Gao
Hangzhou Clinical College, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, China
Xiaomin Ye
Key Laboratory of Kidney Disease Prevention and Control Technology, Department of Nephrology, Hangzhou Hospital of Traditional Chinese Medicine, 453 Tiyu Road, Xihu District, Hangzhou 310012, China
Lidan Hu
Department of Nephrology, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, 3333 Binsheng Road, Binjiang District, Hangzhou 310003, China
Yayu Li
Key Laboratory of Kidney Disease Prevention and Control Technology, Department of Nephrology, Hangzhou Hospital of Traditional Chinese Medicine, 453 Tiyu Road, Xihu District, Hangzhou 310012, China
This study analyzed 550 hemodialysis patients, 469 unvaccinated and 81 vaccinated against COVID-19, to assess the impact on infection rates, mortality, and clinical/laboratory parameters. Gender distribution was similar (p = 0.209), but the vaccinated group’s median age was significantly lower (p = 0.005). Hospitalization rates showed no significant difference (p = 0.987), while mortality was lower in the vaccinated group (p = 0.041). Only uric acid levels were significantly higher in the vaccinated group (p = 0.009); other parameters, including creatinine and B-type natriuretic peptide, showed no significant differences. Age was an independent predictor of mortality (HR = 1.07, p p = 0.308). Logistic regression identified age and dialysis duration as significant mortality factors. Monthly death counts indicated higher mortality among unvaccinated patients during peak pandemic months, suggesting that vaccination provides some protection, though no significant long-term survival benefit was found.
