The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans

Shiuli Agarwal; Tim Vierbuchen; Sreya Ghosh; Jennie Chan; Zhaozhao Jiang; Richard K. Kandasamy; Emiliano Ricci; Katherine A. Fitzgerald

doi:10.1038/s41467-020-20165-5

Nature Communications (Dec 2020)

The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans

Shiuli Agarwal,
Tim Vierbuchen,
Sreya Ghosh,
Jennie Chan,
Zhaozhao Jiang,
Richard K. Kandasamy,
Emiliano Ricci,
Katherine A. Fitzgerald

Affiliations

Shiuli Agarwal: Program in Innate Immunity, University of Massachusetts Medical School
Tim Vierbuchen: Program in Innate Immunity, University of Massachusetts Medical School
Sreya Ghosh: Program in Innate Immunity, University of Massachusetts Medical School
Jennie Chan: Program in Innate Immunity, University of Massachusetts Medical School
Zhaozhao Jiang: Program in Innate Immunity, University of Massachusetts Medical School
Richard K. Kandasamy: Centre of Molecular Inflammation Research (CEMIR), Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology
Emiliano Ricci: Université de Lyon, ENSL, UCBL, CNRS, INSERM, LBMC
Katherine A. Fitzgerald: Program in Innate Immunity, University of Massachusetts Medical School

DOI: https://doi.org/10.1038/s41467-020-20165-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

Read online

lncRNAs are transcriptional regulators, but little is known of them functioning as negative feedback regulators of inflammation in humans. Here, the authors show that the human lncRNA LUCAT1 sequesters STAT1 to limit JAK/STAT signaling and the inflammatory response to viral infection or TLR stimulation in myeloid cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal