Nature Communications (Oct 2020)
Intermolecular channels direct crystal orientation in mineralized collagen
- YiFei Xu,
- Fabio Nudelman,
- E. Deniz Eren,
- Maarten J. M. Wirix,
- Bram Cantaert,
- Wouter H. Nijhuis,
- Daniel Hermida-Merino,
- Giuseppe Portale,
- Paul H. H. Bomans,
- Christian Ottmann,
- Heiner Friedrich,
- Wim Bras,
- Anat Akiva,
- Joseph P. R. O. Orgel,
- Fiona C. Meldrum,
- Nico Sommerdijk
Affiliations
- YiFei Xu
- Department of Chemical Engineering and Chemistry, Laboratory of Materials and Interface Chemistry and Center for Multiscale Electron Microscopy, Eindhoven University of Technology
- Fabio Nudelman
- Department of Chemical Engineering and Chemistry, Laboratory of Materials and Interface Chemistry and Center for Multiscale Electron Microscopy, Eindhoven University of Technology
- E. Deniz Eren
- Institute for Complex Molecular Systems, Eindhoven University of Technology
- Maarten J. M. Wirix
- Department of Chemical Engineering and Chemistry, Laboratory of Materials and Interface Chemistry and Center for Multiscale Electron Microscopy, Eindhoven University of Technology
- Bram Cantaert
- School of Chemistry, University of Leeds
- Wouter H. Nijhuis
- Department of Orthopaedic Surgery, University Medical Centre Utrecht, Wilhelmina Children’s Hospital
- Daniel Hermida-Merino
- Netherlands Organization for Scientific Research (NWO), DUBBLE@ESRF
- Giuseppe Portale
- Netherlands Organization for Scientific Research (NWO), DUBBLE@ESRF
- Paul H. H. Bomans
- Department of Chemical Engineering and Chemistry, Laboratory of Materials and Interface Chemistry and Center for Multiscale Electron Microscopy, Eindhoven University of Technology
- Christian Ottmann
- Institute for Complex Molecular Systems, Eindhoven University of Technology
- Heiner Friedrich
- Institute for Complex Molecular Systems, Eindhoven University of Technology
- Wim Bras
- Netherlands Organization for Scientific Research (NWO), DUBBLE@ESRF
- Anat Akiva
- Department of Chemical Engineering and Chemistry, Laboratory of Materials and Interface Chemistry and Center for Multiscale Electron Microscopy, Eindhoven University of Technology
- Joseph P. R. O. Orgel
- Departments of Biology, Physics and Biomedical Engineering, Pritzker Institute of Biomedical Science and Engineering, Illinois Institute of Technology
- Fiona C. Meldrum
- School of Chemistry, University of Leeds
- Nico Sommerdijk
- Department of Chemical Engineering and Chemistry, Laboratory of Materials and Interface Chemistry and Center for Multiscale Electron Microscopy, Eindhoven University of Technology
- DOI
- https://doi.org/10.1038/s41467-020-18846-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Mineralized collagen is the building block of bone but how the collagen directs hydroxyapatite formation remains unclear. Here, the authors demonstrate cylindrical pores in collagen and how the anisotropic growth of hydroxyapatite directs the orientation of crystal growth in mineralized collagen.
