Nature Communications (Feb 2023)
Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance
- Daniel J. Fazakerley,
- Julian van Gerwen,
- Kristen C. Cooke,
- Xiaowen Duan,
- Elise J. Needham,
- Alexis Díaz-Vegas,
- Søren Madsen,
- Dougall M. Norris,
- Amber S. Shun-Shion,
- James R. Krycer,
- James G. Burchfield,
- Pengyi Yang,
- Mark R. Wade,
- Joseph T. Brozinick,
- David E. James,
- Sean J. Humphrey
Affiliations
- Daniel J. Fazakerley
- Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney
- Julian van Gerwen
- Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney
- Kristen C. Cooke
- Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney
- Xiaowen Duan
- Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney
- Elise J. Needham
- Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney
- Alexis Díaz-Vegas
- Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney
- Søren Madsen
- Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney
- Dougall M. Norris
- Metabolic Research Laboratories, Wellcome-Medical Research Council Institute of Metabolic Science, University of Cambridge
- Amber S. Shun-Shion
- Metabolic Research Laboratories, Wellcome-Medical Research Council Institute of Metabolic Science, University of Cambridge
- James R. Krycer
- Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney
- James G. Burchfield
- Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney
- Pengyi Yang
- Charles Perkins Centre, School of Mathematics and Statistics, University of Sydney
- Mark R. Wade
- Lilly Research Laboratories, Division of Eli Lilly and Company
- Joseph T. Brozinick
- Lilly Research Laboratories, Division of Eli Lilly and Company
- David E. James
- Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney
- Sean J. Humphrey
- Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney
- DOI
- https://doi.org/10.1038/s41467-023-36549-2
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 20
Abstract
The failure of metabolic tissues to respond to insulin is an early marker of type 2 diabetes. Here, the authors show, using global phosphoproteomics, that insulin resistance is caused by a marked rewiring of both canonical and non-canonical insulin signalling, and includes dysregulated GSK3 activity.
