Next-Generation 3D Scaffolds for Nano-Based Chemotherapeutics Delivery and Cancer Treatment
S. M. Shatil Shahriar,
Syed Muntazir Andrabi,
Farhana Islam,
Jeong Man An,
Samantha J. Schindler,
Mitchell P. Matis,
Dong Yun Lee,
Yong-kyu Lee
Affiliations
S. M. Shatil Shahriar
Eppley Institute for Research in Cancer and Allied Diseases, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
Syed Muntazir Andrabi
Department of Surgery—Transplant and Mary & Dick Holland Regenerative Medicine Program, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
Farhana Islam
Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
Jeong Man An
Department of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of Korea
Samantha J. Schindler
College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
Mitchell P. Matis
Kansas City Internal Medicine Residency Program, HCA Healthcare, Overland Park, KS 66215, USA
Dong Yun Lee
Department of Bioengineering, College of Engineering, and BK21 PLUS Future Biopharmaceutical Human Resources Training and Research Team, Hanyang University, Seoul 04763, Republic of Korea
Yong-kyu Lee
4D Biomaterials Center, Korea National University of Transportation, Jeungpyeong 27909, Republic of Korea
Cancer is the leading cause of death after cardiovascular disease. Despite significant advances in cancer research over the past few decades, it is almost impossible to cure end-stage cancer patients and bring them to remission. Adverse effects of chemotherapy are mainly caused by the accumulation of chemotherapeutic agents in normal tissues, and drug resistance hinders the potential therapeutic effects and curing of this disease. New drug formulations need to be developed to overcome these problems and increase the therapeutic index of chemotherapeutics. As a chemotherapeutic delivery platform, three-dimensional (3D) scaffolds are an up-and-coming option because they can respond to biological factors, modify their properties accordingly, and promote site-specific chemotherapeutic deliveries in a sustainable and controlled release manner. This review paper focuses on the features and applications of the variety of 3D scaffold-based nano-delivery systems that could be used to improve local cancer therapy by selectively delivering chemotherapeutics to the target sites in future.
