Oncogenic ACSM6 impairs CD8+ T cell-based immune response in bladder cancer

Abstract

Abstract Resistance to immunotherapy in bladder cancer has greatly limited its clinical application. Through single-cell sequencing, we determined that ACSM6, an oncogene that is highly expressed in bladder cancer, promotes the abilities of proliferation, cloning, migration, and invasion. The key point is that ACSM6 can also lead to a non-inflammatory immune microenvironment by inhibiting the chemotaxis and tumor killing ability of CD8+ T cells. Survival analysis revealed that high ACSM6 expression was associated with shorter overall survival in the immunotherapy cohort. In summary, ACSM6 is expected to become a novel biomarker for predict bladder cancer progression.

Keywords

• Bladder cancer
• Tumor microenvironment
• Immunotherapy resistance
• Non-inflammatory immune microenvironment
• ACSM6