Targeting CISH enhances natural cytotoxicity receptor signaling and reduces NK cell exhaustion to improve solid tumor immunity

• Eric Vivier,
• Daniel Olive,
• Remy Castellano,
• Els Verhoeyen,
• Pierre-Louis Bernard,
• Rebecca Delconte,
• Sonia Pastor,
• Vladimir Laletin,
• Cathy Costa Da Silva,
• Armelle Goubard,
• Emmanuelle Josselin,
• Adrien Krug,
• Julien Vernerey,
• Raynier Devillier,
• Nicholas D Huntington,
• Jacques Nunes,
• Geoffrey Guittard

Affiliations

Eric Vivier

Aff30 grid.417850.f0000000406395277Centre d’Immunologie de Marseille-Luminy Marseille France

Daniel Olive

2CRCM, Marseille, France

Remy Castellano

2CRCM, Marseille, France

Els Verhoeyen

CIRI, Université de Lyon, INSERM U1111, ENS de Lyon, Université Lyon 1, Lyon, France

Pierre-Louis Bernard

Immunity and Cancer Team, Onco-Hemato Immuno-Onco Department, OHIO, Institut Paoli-Calmettes, Inserm, CNRS, Cancer Research Centre, CRCM, Marseille, France

Rebecca Delconte

Immunology Program, Sloan-Kettering Institute, New York City, New York, USA

Sonia Pastor

Immunity and Cancer Team, Onco-Hemato Immuno-Onco Department, OHIO, Institut Paoli-Calmettes, Inserm, CNRS, Cancer Research Centre, CRCM, Marseille, France

Vladimir Laletin

Immunity and Cancer Team, Onco-Hemato Immuno-Onco Department, OHIO, Institut Paoli-Calmettes, Inserm, CNRS, Cancer Research Centre, CRCM, Marseille, France

Cathy Costa Da Silva

Immunity and Cancer Team, Onco-Hemato Immuno-Onco Department, OHIO, Institut Paoli-Calmettes, Inserm, CNRS, Cancer Research Centre, CRCM, Marseille, France

Armelle Goubard

Immunity and Cancer Team, Onco-Hemato Immuno-Onco Department, OHIO, Institut Paoli-Calmettes, Inserm, CNRS, Cancer Research Centre, CRCM, Marseille, France

Emmanuelle Josselin

Immunity and Cancer Team, Onco-Hemato Immuno-Onco Department, OHIO, Institut Paoli-Calmettes, Inserm, CNRS, Cancer Research Centre, CRCM, Marseille, France

Adrien Krug

INSERM, Unité 1111, Université Claude Bernard Lyon 1, Centre National de la Recherche Scientifique, Unité Mixte de Recherche (UMR) 5308, CIRI-International Center for Infectiology Research, Nice, France

Julien Vernerey

Immunity and Cancer Team, Onco-Hemato Immuno-Onco Department, OHIO, Institut Paoli-Calmettes, Inserm, CNRS, Cancer Research Centre, CRCM, Marseille, France

Raynier Devillier

Immunity and Cancer Team, Onco-Hemato Immuno-Onco Department, OHIO, Institut Paoli-Calmettes, Inserm, CNRS, Cancer Research Centre, CRCM, Marseille, France

Nicholas D Huntington

Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia

Jacques Nunes

Immunity and Cancer Team, Onco-Hemato Immuno-Onco Department, OHIO, Institut Paoli-Calmettes, Inserm, CNRS, Cancer Research Centre, CRCM, Marseille, France

Geoffrey Guittard

Immunity and Cancer Team, Onco-Hemato Immuno-Onco Department, OHIO, Institut Paoli-Calmettes, Inserm, CNRS, Cancer Research Centre, CRCM, Marseille, France