Protocol for Dental Management in a Patient with Glucose6-Phosphate Dehydrogenase Deficiency

Abstract

Glucose-6-Phosphate Dehydrogenase (G6PD) enzyme deficiency is the most common inherited genetic disorder affecting RBCs in humans. The disorder is characterised by inability of RBC to maintain a balanced redox state when challenged by oxidative stresses like drugs, infections and certain food substances leading to severe haemolytic anaemia which complicates any therapeutic management in these patients. This article reports on a successful endodontic management of a 36-year-old class III G6PD deficient male patient with deep carious lesion in left mandibular first molar tooth (36). Considering there is no protocol precedence in dental literature, in consultation with the physician/haemotologist a three step protocol for safe and efficient dental management is proposed.

Keywords

• Acute haemolytic anaemia
• Endodontic therapy
• Favism
• G6PD deficiency