Selective Synthesis of Fluorinated Compounds: Process Development and Preparation of Fluorinated Compounds from Gram up to Kilogram Scale

Abstract

The most versatile fluorination reactions for the preparation of up to kg amounts of fluorinated compounds are presented, i.e. the deoxofluorination of alcohols, oxo compounds and carboxylic acids using SF4, and the conversion of anilines to fluoro aromatics. Furthermore the enantioselective catalytic fluorination of ? -ketoesters is highlighted. The option of outsourcing preparative fluorination is discussed.

Keywords

• Benzotrifluorides
• Deoxofluorination
• Fluorination
• Fluoroaromatics
• Schiemann reaction