Histological evaluation of the efficacy of Centella asiatica and bisabolol ointment in thermal injuries

Abstract

Centella asiatica is widely used for its antimicrobial, antioxidant, anti-inflammatory, neuroprotective and wound-healing properties. Bisabolol is an unsaturated sesquiterpene found in increased amounts in chamomile and clary sage oil known for its multiple skin-repairing and soothing virtues. The aim of the present research was to histologically evaluate the efficacy of ointment with Centella asiatica extract and bisabolol. 14 mice from the balb/c line were included in the study, which were divided into 2 groups (experimental, control) and each animal included in the study was clipped before applying the mechanical burn. The duration of the experiment was 14 days with collections of biological material at 3.7 and 14 days. Following the study, we found that, in thermal burns, the use of ointment in which Centella asiatica 2% and bisabolol 1% were incorporated speeds up the skin healing process, compared to the untreated injury, and prevents bacterial superinfections from setting in.

Keywords

• centella asiatica
• bisabolol
• burn
• scarring
• histological evaluation