Relationship between clonal evolution and drug resistance in bladder cancer: A genomic research review

Zhouting Tuo; Ying Zhang; Dengxiong Li; Yetong Wang; Ruicheng Wu; Jie Wang; Qingxin Yu; Luxia Ye; Fanglin Shao; Dilinaer Wusiman; Yubo Yang; Koo Han Yoo; Mang Ke; Uzoamaka Adaobi Okoli; William C. Cho; Susan Heavey; Wuran Wei; Dechao Feng

Pharmacological Research (Aug 2024)

Relationship between clonal evolution and drug resistance in bladder cancer: A genomic research review

Zhouting Tuo,
Ying Zhang,
Dengxiong Li,
Yetong Wang,
Ruicheng Wu,
Jie Wang,
Qingxin Yu,
Luxia Ye,
Fanglin Shao,
Dilinaer Wusiman,
Yubo Yang,
Koo Han Yoo,
Mang Ke,
Uzoamaka Adaobi Okoli,
William C. Cho,
Susan Heavey,
Wuran Wei,
Dechao Feng

Affiliations

Zhouting Tuo: Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China
Ying Zhang: Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China
Dengxiong Li: Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China
Yetong Wang: The Fourth Corps of Students of the Basic Medical College, Army Medical University, Chongqing 400038, China
Ruicheng Wu: Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China
Jie Wang: Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China
Qingxin Yu: Department of Pathology, Ningbo Clinical Pathology Diagnosis Center, Ningbo City, Zhejiang Province 315211, China
Luxia Ye: Department of Public Research Platform, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China
Fanglin Shao: Department of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China
Dilinaer Wusiman: Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN 47907, USA
Yubo Yang: Department of Urology, Three Gorges Hospital, Chongqing University, Chongqing, Wanzhou 404000, China
Koo Han Yoo: Department of Urology, Kyung Hee University, South Korea
Mang Ke: Department of Urology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China
Uzoamaka Adaobi Okoli: Division of Surgery & Interventional Science, University College London, London W1W 7TS, UK; Basic and Translational Cancer Research Group, Department of Pharmacology and Therapeutics, College of Medicine, University of Nigeria, Nsukka, Enugu State, Nigeria
William C. Cho: Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong SAR China; Corresponding authors.
Susan Heavey: Division of Surgery & Interventional Science, University College London, London W1W 7TS, UK; Corresponding authors.
Wuran Wei: Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China; Corresponding authors.
Dechao Feng: Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China; Division of Surgery & Interventional Science, University College London, London W1W 7TS, UK; Corresponding authors.

Journal volume & issue: Vol. 206
p. 107302

Abstract

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Bladder cancer stands as a prevalent global malignancy, exhibiting notable sex-based variations in both incidence and prognosis. Despite substantial strides in therapeutic approaches, the formidable challenge of drug resistance persists. The genomic landscape of bladder cancer, characterized by intricate clonal heterogeneity, emerges as a pivotal determinant in fostering this resistance. Clonal evolution, encapsulating the dynamic transformations within subpopulations of tumor cells over time, is implicated in the emergence of drug-resistant traits. Within this review, we illuminate contemporary insights into the role of clonal evolution in bladder cancer, elucidating its influence as a driver in tumor initiation, disease progression, and the formidable obstacle of therapy resistance.

Published in Pharmacological Research

ISSN: 1096-1186 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.sciencedirect.com/journal/pharmacological-research

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