The role of genetic polymorphisms of the VEGF, COX2, MUC genes in the development of endometriosis-associated infertility

Abstract

Endometriosis-associated infertility is an important medical and social problem, because affects up to 10% of women in the reproductive case, while even after treatment the pregnancy occurs in only one third of the patients. The etiology of endometriosis is still not precisely defined, despite ongoing research on this topic. In this review of the literature, we have tried to highlight the main work concerning the participation of immunological and genetic factors in the pathogenesis, and the role of vascular endothelial growth factor, mucins and cyclooxygenase-2 in more detail. Further studies of these pathogenetic manifestations of infertility in patients with endometriosis will make it possible to correct them in a timely manner, thereby increasing the chances of pregnancy.

Keywords

• endometriosis-associated infertility
• mucins
• vascular endothelial growth factor
• cyclooxygenase-2
• miscarriage
• pregnancy
• reproductive loss