BEN-solo factors partition active chromatin to ensure proper gene activation in Drosophila

Malin Ueberschär; Huazhen Wang; Chun Zhang; Shu Kondo; Tsutomu Aoki; Paul Schedl; Eric C. Lai; Jiayu Wen; Qi Dai

doi:10.1038/s41467-019-13558-8

Nature Communications (Dec 2019)

BEN-solo factors partition active chromatin to ensure proper gene activation in Drosophila

Malin Ueberschär,
Huazhen Wang,
Chun Zhang,
Shu Kondo,
Tsutomu Aoki,
Paul Schedl,
Eric C. Lai,
Jiayu Wen,
Qi Dai

Affiliations

Malin Ueberschär: Department of Molecular Bioscience, the Wenner-Gren Institute, Stockholm University
Huazhen Wang: Department of Molecular Bioscience, the Wenner-Gren Institute, Stockholm University
Chun Zhang: Department of Molecular Bioscience, the Wenner-Gren Institute, Stockholm University
Shu Kondo: Laboratory of Invertebrate Genetics, National Institute of Genetics
Tsutomu Aoki: Department of Molecular Biology, Princeton University
Paul Schedl: Department of Molecular Biology, Princeton University
Eric C. Lai: Department of Developmental Biology, Memorial Sloan Kettering Institute
Jiayu Wen: Department of Genome Sciences, The John Curtin School of Medical Research, The Australian National University
Qi Dai: Department of Molecular Bioscience, the Wenner-Gren Institute, Stockholm University

DOI: https://doi.org/10.1038/s41467-019-13558-8
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

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The BEN-solo proteins—including Insensitive (Insv), Elba1 and Elba2—function in both transcriptional repression and chromatin insulation. Here, the authors investigate the role of these proteins in Drosophila embryos, finding that ELBA and Insv function as general insulators and partition active chromatin to ensure proper gene activation in Drosophila.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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