Clinical Pregnancy and Miscarriage Rates in relation to Vitamin D Supplementation among women with Hyper Androgenic PCOS: A prospective study

Abstract

Background Given pregnant mothers' high frequency of vitamin D (25(OH)D) deficiency and the potential consequences for the health of the unborn child. Prenatal vitamin D administration raises maternal and baby 25(OH)D levels.Aims to assess the 25(OH)D supplementation effects on rate of clinical pregnancy and miscarriage in women with hyper androgenic polycystic ovarian disorder. Methods A prospective study was conducted on 200 patients with hyper androgenic polycystic ovarian disease, at outpatient infertility clinic, Menoufia University Hospital during from March 2021 till March 2022. The cases divided into group (A) included 100 women given a therapeutic dose of 25(OH)D supplements, while group (B) included 100 women didn't given 25(OH)D supplements. Results duration needed to reach follicle ≥18 mm was significantly higher among group B (16.74±2.57), compared with group A (13.40±2.12). While, midluteal progesterone was significantly higher among group A (19.63±2.12), compared with group B (17.74±2.36), (P<0.001). Our results indicate that women who have enough 25(OH)D are far more likely to get clinically pregnant than those who had deficiency of 25(OH)D.Conclusion More research is necessary to determine whether vitamin D supplementation can increase pregnancy rates in a simple and economical manner. In our study population, there was a significant prevalence of 25(OH)D deficit or insufficiency. Determining 25(OH)D status as part of a routine infertility assessment may therefore be advantageous.

Keywords

• hyperandrogenic
• polycystic ovarian syndrome
• pregnancy outcomes
• vitamin d