Indications of Pregnancy Termination in Patients With Preterm Premature Rupture of Membranes and Relationship Between the Latency of Rupture and Pregnancy Outcomes

Abstract

Objectives: Evidence indicates that maternal and neonatal complications increase in pregnancies with preterm premature rupture of the membranes (PPROM). Therefore, the present study aimed to evaluate the indications of pregnancy termination with PPROM and the effect of PPROM latency on maternal and neonatal outcomes. Materials and Methods: This prospective study was conducted on pregnant women who were admitted with PPROM. The patients were divided into two groups based on their gestational age. The first group consisted of women with less than 30 weeks of gestation and the second group included those with 30 to 33 weeks and 6 days of gestation. The data on the indications of termination, amniotic fluid index, and latency and their relation to neonatal and maternal complications were evaluated based on the aim of the study. Results: The study included 199 patients with a mean (standard deviation) age of 29.6±3.4. Based on the results, the most frequent indications for pregnancy termination were reaching 34 weeks of gestation and labor onset. In addition, the chorioamnionitis in 3 cases (1.5%) was the most common maternal complication. Finally, the median of latency was 5 (3-10) and 3 (1-6) days in groups 1 and 2, (P=0.001). Conclusions: In general, the results of the present study suggest that the latency of PPROM in less than 30 weeks of gestational age improves the neonatal mortality rate without increasing maternal and neonatal adverse outcomes.

Keywords

• latency
• preterm premature rupture of membrane
• neonatal complication
• maternal complication