Nature Communications (Aug 2016)

A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection

  • Ana López-Saavedra,
  • Daniel Gómez-Cabello,
  • María Salud Domínguez-Sánchez,
  • Fernando Mejías-Navarro,
  • María Jesús Fernández-Ávila,
  • Christoffel Dinant,
  • María Isabel Martínez-Macías,
  • Jiri Bartek,
  • Pablo Huertas

DOI
https://doi.org/10.1038/ncomms12364
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

Read online

A DNA double strand break can be repaired through either the non-homologous end-joining or the homologous recombination pathways. Here the authors conduct a genome-wide screen and identify a role for CCAR2 in pathway choice by regulating DNA end resection by CtIP.